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[The relationship between serum parathormone levels and the severity of coronary artery disease]
Derya Oztürk1, Ozlem Ozcan Çelebi, Feridun Vasfi Ulusoy
1Department of Cardiology, Gelibolu State Hospital, Çanakkale, Trukey. dr.deryaerbas@hotmail.com
Insights
Serum parathormone (PTH) levels were not found to correlate with the severity of coronary artery disease (CAD). This study indicates PTH does not determine the extent of atherosclerosis in patients undergoing coronary angiography.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Clinical Research
Context:
- Elevated parathormone (PTH) is suspected to negatively impact cardiovascular health.
- The association between PTH and coronary artery disease (CAD) remains under investigation.
- Understanding this relationship is crucial for cardiovascular risk assessment.
Purpose:
- To investigate the correlation between serum PTH levels and the extent of CAD.
- To determine if PTH levels can predict the severity of coronary atherosclerosis.
Summary:
- This study analyzed 260 patients undergoing coronary angiography.
- Serum PTH levels were measured and correlated with Gensini scores, a measure of CAD extent.
- No significant difference in PTH levels was observed across varying degrees of coronary artery disease severity.
Impact:
- Findings suggest serum PTH levels are not a reliable indicator for the extent of CAD.
- This research contributes to clarifying the complex relationship between PTH and cardiovascular disease.
- Results may influence future diagnostic or prognostic strategies for CAD.
Objectives:
It has been reported that increased parathormone (PTH) levels have unfavorable effects on the cardiovascular system. PTH produces unfavorable effects via either PTH receptors or the renin angiotensin aldosterone system. Data shows that there is a relationship between PTH and coronary artery disease (CAD), although this relationship is still being debated. In this study, we evaluate the relationship between serum PTH levels and CAD.
Study Design:
The study included 260 patients (125 males, 135 females, mean age 56.01±11.9 years) who underwent coronary angiography with a prediagnosis of CAD. Venous blood samples were taken 6 hours before the coronary angiography for the measurement of serum PTH levels. The extent of CAD was evaluated by calculation of Gensini scores.
Results:
The Gensini score was 0 in 99 of the patients. Mild atherosclerosis and severe atherosclerosis were determined in 67 and 94 patients, respectively. According to the Gensini score, serum PTH levels were 5.17±2.07 pmol/l, 4.88±2.40 pmol/l and 4.98±3.04 pmol/l, respectively. PTH levels were similar in patients with mild atherosclerosis and with normal coronary arteries (Gensini score 0) (p=0.55). There was no difference in PTH levels between patients with mild and severe atherosclerosis (p=0.77). In addition, no significant difference in PTH levels were detected between those with normal coronary arteries and those with severe atherosclerosis (p=0.78).
Conclusion:
Serum PTH level does not determine the extensity of CAD.
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