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A probiotics-containing biscuit modulates the intestinal microbiota in the elderly
S Rampelli1, M Candela, M Severgnini
1Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy.
The Journal of Nutrition, Health & Aging
|February 1, 2013
Summary
Consuming a probiotic biscuit for one month helped to correct age-related gut microbiota imbalances in elderly individuals. This intervention reduced harmful bacteria, suggesting a potential for probiotic foods to support healthy aging.
Area of Science:
- Gastroenterology
- Microbiology
- Nutrition Science
Background:
- Aging is associated with dysbiosis, an imbalance in the gut microbiota.
- This dysbiosis can lead to an increase in opportunistic pathogens.
- Probiotics show potential in modulating the gut microbiome.
Purpose of the Study:
- To evaluate the impact of a biscuit containing Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 on the elderly intestinal microbiota.
- To assess the efficacy of probiotics in counteracting age-related gut dysbiosis.
Main Methods:
- Randomized, double-blind, placebo-controlled trial.
- 32 elderly volunteers (71-88 years) consumed a probiotic biscuit or placebo daily for 30 days.
- Intestinal microbiota was analyzed using the HTF-Microbi.Array platform before and after intervention.
Main Results:
- One-month consumption of the probiotic biscuit effectively redressed age-related intestinal dysbioses.
- Probiotic treatment reverted the age-related increase of opportunistic pathogens like Clostridium clusters, Clostridium difficile, Clostridium perfringens, Enterococcus faecium, and Campylobacter.
Conclusions:
- Probiotic-containing biscuits can counteract age-related gut microbiota dysbiosis in the elderly.
- This study supports the development of functional foods tailored for elderly populations to improve gut health.
- Probiotic interventions may offer a strategy to manage age-related microbial shifts.
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