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Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters01:16

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

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Related Experiment Video

Updated: May 14, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

A single-nucleotide polymorphism in SCN9A may decrease postoperative pain sensitivity in the general population.

Guangyou Duan1, Guifang Xiang, Xianwei Zhang

  • 1Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Anesthesiology
|February 1, 2013
PubMed
Summary

The SCN9A 3312T allele is associated with reduced postoperative pain sensitivity and a lower risk of inadequate analgesia. This genetic variant may help predict individual pain perception and response to pain management.

Related Experiment Videos

Last Updated: May 14, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

Area of Science:

  • Genetics
  • Pain Research
  • Pharmacogenomics

Background:

  • Congenital indifference to pain is linked to SCN9A gene variations.
  • A specific SCN9A polymorphism (3312G>T) is found in both pain-insensitive individuals and healthy controls.
  • The predictive role of this polymorphism in general population pain perception is unclear.

Purpose of the Study:

  • To investigate the predictive value of the SCN9A 3312G>T polymorphism for baseline pain perception.
  • To assess the impact of this SCN9A variant on postoperative pain sensitivity and analgesic requirements.
  • To determine if the 3312G>T allele influences the incidence of inadequate analgesia after surgery.

Main Methods:

  • 200 patients undergoing pancreatectomy had preoperative pain thresholds and tolerance measured.
  • Postoperative pain sensitivity and patient-controlled analgesia (PCA) demand were recorded.
  • SCN9A 3312G>T allele status was analyzed, and logistic regression identified predictors of inadequate analgesia.

Main Results:

  • The 3312T allele was present in 5.5% of patients.
  • Patients with the 3312T allele showed significantly lower PCA pressing frequency and opioid consumption compared to 3312G allele carriers.
  • The incidence of inadequate analgesia was substantially lower in 3312T allele carriers (4.5% vs. 29.2%).

Conclusions:

  • The SCN9A 3312T allele is associated with reduced postoperative pain sensitivity.
  • Carrying the 3312T allele significantly lowers the likelihood of experiencing inadequate analgesia.
  • This genetic variant may serve as a biomarker for predicting pain response and optimizing analgesia strategies.