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Updated: May 14, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

Transient receptor potential canonical type 3 channels--their evolving role in hypertension and its related

Peijian Wang1, Daoyan Liu, Martin Tepel

  • 1Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China.

Journal of Cardiovascular Pharmacology
|February 1, 2013
PubMed

Insights

Transient receptor potential canonical type 3 (TRPC3) channels are crucial for blood pressure regulation. TRPC3 dysfunction is linked to hypertension and cardiovascular diseases, highlighting their pathological role.

Area of Science:

  • Cardiovascular Physiology
  • Renal Physiology
  • Molecular Biology

Background:

  • Transient receptor potential canonical type 3 (TRPC3) channels play a role in cardiovascular homeostasis.
  • TRPC3 dysfunction is implicated in various cardiovascular pathologies, including hypertension and atherosclerosis.
  • Understanding TRPC3's role is vital for addressing cardiovascular diseases.

Purpose of the Study:

  • To review the function of TRPC3 channels in the cardiovascular system.
  • To elucidate the pathophysiological role of TRPC3 in hypertension.
  • To explore TRPC3's involvement in target organ damage associated with hypertension.

Main Methods:

  • Literature review of recent studies on TRPC3 channels.
  • Analysis of TRPC3's contribution to blood pressure regulation.
  • Examination of TRPC3's role in hypertension and related organ damage.

Main Results:

  • TRPC3 channels are key regulators of blood pressure.
  • TRPC3 dysfunction is associated with hypertension, atherosclerosis, cardiac hypertrophy, and cerebrovascular events.
  • TRPC3 channels are involved in the development of hypertension and its complications.

Conclusions:

  • TRPC3 channels are critical for cardiovascular and renal function.
  • TRPC3 dysfunction contributes significantly to the development and progression of hypertension.
  • Targeting TRPC3 channels may offer therapeutic strategies for hypertension and associated organ damage.

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