Related Experiment Video

Updated: Feb 16, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
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[Loco-regional transcatheter thrombolysis]

E Camerini1, D Trippi, C Vignali

  • 1Istituto di Radiologia, Università, Pisa.

La Radiologia Medica
|March 1, 1990
PubMed

Insights

Local urokinase injection effectively treated arterial thrombosis, including popliteal and bypass graft thromboses. This interventional radiology approach achieved successful arterial recanalization and restored patency in all cases within 72 hours.

Area of Science:

  • Vascular Surgery
  • Interventional Radiology
  • Cardiovascular Medicine

Background:

  • Arterial thrombosis in bypass grafts and popliteal arteries poses a significant clinical challenge.
  • Timely restoration of blood flow is crucial to prevent limb ischemia.

Purpose of the Study:

  • To evaluate the efficacy of local urokinase injection for treating recent arterial thrombosis.
  • To assess outcomes in patients with popliteal and prosthetic arterial thromboses.

Main Methods:

  • Eight patients with recent arterial thrombosis (popliteal and prosthetic bypasses) were treated.
  • Percutaneous catheterization with local urokinase injection (bolus and infusion) was performed.
  • Adjunctive heparin therapy and percutaneous transluminal angioplasty (PTA) were utilized in select cases.

Main Results:

  • Complete arterial recanalization was achieved in all eight cases within 72 hours.
  • Successful patency was restored in 2 aorto-bifemoral bypasses and 2 popliteal thromboses.
  • One of four femoropopliteal bypasses achieved recanalization.

Conclusions:

  • Local urokinase administration is an effective treatment for acute arterial thrombosis.
  • This minimally invasive approach offers a viable option for restoring arterial patency.
  • Further studies are warranted to optimize treatment protocols for bypass grafts.

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