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High risk of cardiovascular diseases after diagnosis of multiple sclerosis

Elham Jadidi1, Mohammad Mohammadi, Tahereh Moradi

  • 1Institute of Environmental Medicine, Division of Epidemiology, Karolinska Institutet, Stockholm, Sweden.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|February 1, 2013
PubMed

Insights

Multiple sclerosis (MS) patients face higher risks for myocardial infarction, stroke, and heart failure, especially women. Cardiovascular disease (CVD) prevention is crucial for this population.

Area of Science:

  • Neurology
  • Cardiology
  • Epidemiology

Background:

  • Multiple sclerosis (MS) is a chronic neurological condition.
  • Understanding cardiovascular disease (CVD) risks in MS patients is vital for prognosis and outcomes.
  • Existing research may not fully capture CVD risk heterogeneity in MS.

Purpose of the Study:

  • To assess the risk of myocardial infarction (MI), stroke, heart failure (HF), and atrial fibrillation (AF) or flutter in MS patients.
  • To investigate these risks across different ethnicities, sexes, and age groups.
  • To identify specific demographic groups within the MS population that may be at higher risk.

Main Methods:

  • Nationwide population-based cohort study in Sweden.
  • Inclusion of 8,281 MS patients hospitalized between 1987-2009 and 76,640 matched controls.
  • Poisson regression analysis with stratification by sex, age, and country of birth.

Main Results:

  • MS patients showed significantly higher incidence rate ratios for MI (1.85), stroke (1.71), and HF (1.97) compared to controls.
  • A decreased risk was observed for AF/Flutter (0.63) in MS patients.
  • Increased CVD risks were particularly pronounced in women with MS.

Conclusions:

  • MS patients, especially women, require vigilant cardiovascular surveillance and preventive measures.
  • The findings highlight a significant association between MS and increased risk for several major cardiovascular events.
  • Targeted CVD prevention strategies are recommended for the MS population.
Abstract

Keywords:
Multiple sclerosisSwedenatrial fibrillationcardiovascular diseaseepidemiologyethnicityflutterheart failureimmigrantsmyocardial infarctionrisk factorsstroke

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