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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

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Published on: February 12, 2017

Endobronchial metastases from extrathoracic malignancy.

Sang Hoon Lee¹, Ji Ye Jung, Do Hoon Kim

¹Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea.

Yonsei Medical Journal

|February 1, 2013

Summary

Endobronchial metastasis (EBM) can arise from various cancers and present subtly. Physicians should suspect EBM in patients with a history of malignancy, even without respiratory symptoms, for timely intervention.

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Area of Science:

Pulmonology
Oncology
Medical Diagnostics

Background:

Endobronchial metastasis (EBM) involves cancer spread to the airways, mimicking primary lung cancer.
Distinguishing EBM from primary lung cancer is crucial as management and prognosis differ.

Purpose of the Study:

To investigate the clinical, radiologic, and bronchoscopic features of endobronchial metastases (EBM) in Korean patients.
To enhance understanding of EBM presentation and characteristics.

Main Methods:

Retrospective analysis of 43 patients diagnosed with EBM via bronchoscopic biopsy.
Evaluation of clinical, radiologic, and bronchoscopic data from June 1991 to December 2009.

Main Results:

Common primary cancers leading to EBM included rectal (16.3%), colon (11.6%), breast (9.3%), and uterine (9.3%).
The average time from primary cancer diagnosis to EBM was 36 months.
The mean survival after EBM diagnosis was 16.1 months in deceased patients.

Conclusions:

Endobronchial metastasis can manifest from diverse malignancies at various times with non-specific symptoms.
Consider EBM in patients with a history of cancer, irrespective of respiratory complaints.
Safe procedures exist for managing respiratory symptoms associated with EBM.