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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Rapid decrease of intact parathyroid hormone could be a predictor of better response to cinacalcet in hemodialysis
Jwa-Kyung Kim1, Young Joo Kwon, Soo Wan Kim
1Department of Internal Medicine & Kidney Research Institute, Hallym University College of Medicine, Anyang, Korea.
Yonsei Medical Journal
|February 1, 2013
Summary
Cinacalcet effectively treats secondary hyperparathyroidism in hemodialysis patients. Early response to cinacalcet, particularly in diabetics, predicts successful achievement of target intact parathyroid hormone (iPTH) levels.
Area of Science:
- Nephrology
- Endocrinology
- Pharmacology
Background:
- Secondary hyperparathyroidism (SHPT) is common in hemodialysis patients.
- Refractory SHPT requires effective treatment options.
- Cinacalcet is a calcimimetic agent used to manage SHPT.
Purpose of the Study:
- To evaluate the effectiveness of cinacalcet in treating refractory SHPT.
- To determine response rates to cinacalcet therapy.
- To identify clinical factors influencing cinacalcet response in hemodialysis patients.
Main Methods:
- Prospective, single-arm, multi-center study over 24 weeks.
- Cinacalcet administered to patients with intact parathyroid hormone (iPTH) > 300 pg/mL.
- Dose titration from 25 mg to 100 mg daily to achieve iPTH < 300 pg/mL.
Main Results:
- 82.5% of patients responded to cinacalcet.
- Responders were older, more likely female, and had diabetes.
- Lower baseline iPTH, diabetes, and early response were key factors for achieving target iPTH levels.
Conclusions:
- Cinacalcet is effective for refractory SHPT in hemodialysis patients.
- Early response to cinacalcet is a strong predictor of achieving target iPTH levels.
- Diabetes is a significant factor associated with cinacalcet response.
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