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Related Concept Videos

Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...

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Related Experiment Video

Updated: May 14, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Goblet cell carcinoids of the appendix.

Nanna Holt1, Henning Grønbæk

  • 1Department of Medicine V, Aarhus University Hospital, 44 Norrebrogade, 8000 Aarhus C, Denmark. d051398@dadlnet.dk

Thescientificworldjournal
|February 1, 2013
PubMed
Summary

Goblet cell carcinoid (GCC) tumors, a rare appendix neuroendocrine tumor, present with appendicitis-like symptoms. Higher malignancy potential necessitates specialized care, with surgery as primary treatment and chemotherapy for advanced cases.

Related Experiment Videos

Last Updated: May 14, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Goblet cell carcinoid (GCC) tumors are a rare subtype of neuroendocrine tumors (NETs) predominantly found in the appendix.
  • GCCs often mimic appendicitis clinically, presenting in middle-aged adults, and can exhibit advanced local spread or distant metastases at diagnosis.

Purpose of the Study:

  • To provide an updated review of GCC epidemiology, clinical presentation, and diagnostic markers.
  • To discuss current treatment strategies and survival outcomes for GCC patients.
  • To emphasize the importance of specialized centers for GCC diagnosis and management.

Main Methods:

  • Literature review and synthesis of existing data on GCC.
  • Analysis of diagnostic markers including chromogranin A, synaptophysin, Ki67 index, CEA, CA-19-9, and CA-125.
  • Review of imaging modalities (CT/MRI) and treatment approaches (surgery, chemotherapy).

Main Results:

  • GCCs show less homogenous histological markers (chromogranin A, synaptophysin) compared to classic carcinoids.
  • Proliferation markers like Ki67 index are crucial for determining prognosis.
  • Octreotide scintigraphy is often negative, while CT/MRI can be useful for staging.

Conclusions:

  • GCCs possess a higher malignant potential than typical appendix carcinoids, requiring tailored management.
  • Surgical resection (appendectomy, right hemicolectomy) is the primary treatment; chemotherapy is indicated for disseminated disease.
  • Optimal patient outcomes are achieved through centralized care in high-volume NET centers.