Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a virus that...
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Spatial Biology of HIV Transmission and Infection: Imaging the Female and Male Reproductive Tracts.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same author

A Tissue Virus Microenvironment with Activated Stress Responses Underlies Durable SIV Persistence.

bioRxiv : the preprint server for biology·2026
Same author

Pathological phimosis is associated with foreskin immune cell infiltration but not microbiota composition.

mSphere·2026
Same author

<i>S</i>‑Adenosylhomocysteine Analogs Selectively Suppress Pan-Coronavirus Replication by Inhibition of nsp14 Methyltransferase.

ACS medicinal chemistry letters·2026
Same author

Endocervix exhibits greater susceptibility to HIV-1 infection compared to ectocervix following ex vivo exposure to Transmitted/Founder HIV-1 variants.

PloS one·2025
Same author

Vaginal microbiome dysbiosis and sexually transmitted infections correlate with concentrations of immunoglobulin isotypes in human cervicovaginal mucus: insights into HIV-1 transmission.

Frontiers in immunology·2025
Same journal

Putative Novel Viruses in the Families <i>Lispiviridae</i> and <i>Rhabdoviridae</i> Detected in <i>Culex</i> and <i>Anopheles</i> Mosquitoes Collected at the São Paulo Zoo.

Advances in virology·2026
Same journal

Molecular and Clinical Screening of Selected Feline Viral Infections in Sulaymaniyah, Kurdistan Region, Iraq.

Advances in virology·2026
Same journal

Structural Insights Into the Nuclear Import of Marek's Disease Virus Large Tegument Protein.

Advances in virology·2026
Same journal

HIV-1 Genetic Diversity and Drug Resistance Mutations Among Patients on Antiretroviral Therapy in Nairobi County, Kenya.

Advances in virology·2026
Same journal

Frequency and Demographic Patterns of SARS-CoV-2 and Influenza Virus Infections in Khuzestan: A Retrospective Observational Study (2021-2023).

Advances in virology·2026
Same journal

Molecular Characterization and Genomic Diversity of SARS-CoV-2 Spike Gene Variants Circulating in Iraq: Mutational Impact on ACE2 Affinity, RBD Immune Escape, and Viral Transmission.

Advances in virology·2025
See all related articles

Related Experiment Video

Updated: May 14, 2026

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

Cellular factors implicated in filovirus entry.

Suchita Bhattacharyya1, Thomas J Hope

  • 1University of Mumbai and Department of Atomic Energy-Centre for Excellence in Basic Sciences, Health Centre Building, Vidyanagari, Kalina, Santacruz East, Mumbai 400098, India.

Advances in Virology
|February 1, 2013
PubMed
Summary
This summary is machine-generated.

Filoviruses cause deadly infections and can be biological weapons, necessitating research into their entry mechanisms. Understanding filoviral entry factors is crucial for developing effective antiviral therapies.

More Related Videos

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment
08:34

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

Measuring Attachment and Internalization of Influenza A Virus in A549 Cells by Flow Cytometry
07:25

Measuring Attachment and Internalization of Influenza A Virus in A549 Cells by Flow Cytometry

Published on: November 4, 2015

Related Experiment Videos

Last Updated: May 14, 2026

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment
08:34

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

Measuring Attachment and Internalization of Influenza A Virus in A549 Cells by Flow Cytometry
07:25

Measuring Attachment and Internalization of Influenza A Virus in A549 Cells by Flow Cytometry

Published on: November 4, 2015

Area of Science:

  • Virology
  • Cell Biology
  • Infectious Diseases

Background:

  • Filoviral infections pose significant global health threats and potential bioweapon risks.
  • Current preventive and treatment strategies against filoviruses are lacking.
  • Filovirus entry is a critical step in their replication cycle, involving numerous cellular factors.

Purpose of the Study:

  • To summarize existing literature on filoviral entry mechanisms.
  • To highlight cellular factors implicated in filovirus entry.
  • To identify fundamental questions for future research in filoviral entry.

Main Methods:

  • Literature review of studies on filoviral entry.
  • Focus on cellular factors, including plasma membrane, cytoskeletal, and endosomal components.
  • Examination of signaling molecules like TAM receptor tyrosine kinases and potential receptors (TIM-1, NPC1).

Main Results:

  • Filovirus entry involves a complex interplay of cellular factors.
  • TAM family receptor tyrosine kinases (Tyro3, Axl, Mer) are implicated as entry factors.
  • T-cell immunoglobulin and mucin domain 1 (TIM-1) and Niemann-Pick C1 (NPC1) are proposed as potential filovirus receptors.

Conclusions:

  • Comprehensive understanding of filoviral entry is essential for developing antiviral therapeutics.
  • Further research into identified cellular factors and receptors can guide novel treatment strategies.
  • Addressing fundamental questions in filoviral entry is key to combating these deadly infections.