Effect of gadobutrol on VX2 magnetic resonance diffusion-weighted imaging

The aim of this study was to evaluate the effect of contrast agent gadobutrol on the magnetic resonance diffusion-weighted imaging (MR DWI). Gadobutrol has higher relaxivity than Gd-DTPA and it also has higher formulation 1.0 M than Gd-DTPA 0.5 M. VX2 tumor implanted on the left thigh of each New Zealand rabbit was used as the animal model. The MR scanning was performed using a 1.5 T clinical whole-body MR scanner with an 8-channel knee coil. The results showed that there were significant differences in the signal-to-noise ratio (SNR) and apparent diffusion coefficient (ADC) values between tumor and muscle both before and after gadobutrol injection (0.1 mmol/kg). However, there were no significant differences in the SNR and ADC values of tumor or muscle before and after gadobutol administration. There were also no significant difference in the contrast-to-noise ratio (CNR) values of tumor and muscle before and after gadobutrol injection.