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Related Experiment Video

Updated: May 14, 2026

Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level

Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level

Published on: November 17, 2013

Experimental glucose regulation with a high-order sliding-mode controller.

Ana Gallardo Hernández¹, Cristina Revilla Monsalve, Leonid Fridman

¹Unidad de Investigación en Enfermedades Metabólicas, Centro Médico Nacional Siglo XXI (IMSS), México. anagabygh@gmail.com

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|February 1, 2013

Summary

High-Order Sliding-Mode Controllers offer robust glucose regulation, proving effective in diabetic rats. This advanced control strategy minimizes disruptions from system uncertainties and external disturbances.

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Last Updated: May 14, 2026

Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level

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Published on: November 17, 2013

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Simple Continuous Glucose Monitoring in Freely Moving Mice

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Published on: February 24, 2023

Area of Science:

Biomedical Engineering
Control Systems
Endocrinology

Background:

Diabetes mellitus poses significant challenges for maintaining stable blood glucose levels.
Accurate glucose regulation is crucial for preventing acute and chronic complications.
Existing control systems may struggle with parameter uncertainties and unmodeled dynamics.

Purpose of the Study:

To implement and evaluate a High-Order Sliding-Mode Controller (HOSMC) for closed-loop glucose regulation.
To assess the controller's robustness against parameter uncertainties and unknown system dynamics.
To validate the controller's efficacy in a preclinical model of diabetes.

Main Methods:

Theoretical design of an HOSMC based on the concept of practical relative degree.
Implementation of the HOSMC for automated glucose control.
In vivo testing of the controller in Sprague-Dawley rats with streptozotocin-induced diabetes.

Main Results:

The HOSMC demonstrated robust performance in closed-loop glucose regulation.
The controller exhibited insensitivity to parameter uncertainties inherent in biological systems.
Effective glucose control was achieved in diabetic rats, indicating high efficacy.

Conclusions:

High-Order Sliding-Mode Controllers are theoretically and practically suitable for closed-loop glucose regulation.
The implemented HOSMC shows significant robustness and efficacy in a preclinical diabetes model.
This control strategy holds promise for advanced diabetes management systems.