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Mutation modification with multiplicative fertility selection.

M J Twomey1, M W Feldman

  • 1Department of Biological Sciences, Stanford University, California 94305.

Theoretical Population Biology
|April 1, 1990
PubMed
Summary
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This study models how a modifier gene influences mutation rates. Recombination and selection determine if mutation rates increase or decrease, with outcomes depending on linkage and initial genetic conditions.

Area of Science:

  • Population genetics
  • Evolutionary genetics
  • Theoretical biology

Background:

  • Understanding the evolution of mutation rates is crucial in evolutionary biology.
  • Genetic drift, mutation, selection, and recombination are key forces shaping genetic variation.
  • The interplay between selection and mutation is complex and depends on various genetic factors.

Purpose of the Study:

  • To model the evolution of mutation rates under selection and recombination.
  • To investigate the conditions under which mutation rates may increase or decrease.
  • To analyze the impact of linked modifier alleles on mutation rate evolution.

Main Methods:

  • Mathematical modeling of two diallelic loci in a large, randomly mating diploid population.
  • Analysis of unidirectional mutation, multiplicative fertility selection, and recombination.

Related Experiment Videos

  • Numerical analysis of 56,000 sample equilibria to determine modifier allele fate.

    • Main Results:

    • The fate of a mutation rate modifier allele depends on its effect and the recombination rate (R).
    • A critical recombination rate (R*) determines whether 'down' or 'up' modifiers invade.
    • Mutation rates can increase, but only if the primary locus would remain polymorphic without mutation.

    Conclusions:

    • Linkage and selection critically influence mutation rate evolution.
    • The evolution of mutation rates is context-dependent, influenced by genetic architecture.
    • This model provides insights into the potential for mutation rate increase in populations.