Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuronal Communication01:28

Neuronal Communication

Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
Neural Circuits01:25

Neural Circuits

Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gaussian splashing enables direct volumetric rendering underwater.

Scientific reports·2026
Same author

Material damage to multielectrode arrays after electrolytic lesioning is insignificant.

eLife·2026
Same author

Stiefel Manifold Dynamical Systems for Tracking Representational Drift.

bioRxiv : the preprint server for biology·2026
Same author

Compression detects changes in spiking neural data from cortical lesions.

Journal of neural engineering·2026
Same author

Textile suit for anywhere full-body motion capture.

Science advances·2026
Same author

Stability of neural manifolds at minimal dimensionality despite motor representational drift.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: May 14, 2026

Decoding Natural Behavior from Neuroethological Embedding
08:00

Decoding Natural Behavior from Neuroethological Embedding

Published on: October 3, 2025

A framework for relating neural activity to freely moving behavior.

Justin D Foster1, Paul Nuyujukian, Oren Freifeld

  • 1Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA. justinf@stanford.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|February 1, 2013
PubMed
Summary
This summary is machine-generated.

Neural activity in the motor cortex reliably predicts complex movements in freely moving monkeys. This supports decoding techniques for brain-computer interfaces, even with varied behaviors and distractions.

More Related Videos

Recordings of Neural Circuit Activation in Freely Behaving Animals
08:53

Recordings of Neural Circuit Activation in Freely Behaving Animals

Published on: July 22, 2009

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments
09:43

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments

Published on: April 15, 2014

Related Experiment Videos

Last Updated: May 14, 2026

Decoding Natural Behavior from Neuroethological Embedding
08:00

Decoding Natural Behavior from Neuroethological Embedding

Published on: October 3, 2025

Recordings of Neural Circuit Activation in Freely Behaving Animals
08:53

Recordings of Neural Circuit Activation in Freely Behaving Animals

Published on: July 22, 2009

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments
09:43

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments

Published on: April 15, 2014

Area of Science:

  • Neuroscience
  • Motor Systems
  • Prosthetics

Background:

  • Motor systems neuroscience and motor prosthetics research explores the link between motor cortex neural activity and movement.
  • Current understanding is based on animal models with constrained behaviors, limiting applicability to real-world scenarios.

Purpose of the Study:

  • To investigate if neural activity in the motor cortex can predict complex, unconstrained behaviors.
  • To assess the viability of decoding techniques in naturalistic settings.

Main Methods:

  • Simultaneous intracortical recording from a monkey during freely-moving behavioral experiments.
  • Analysis of neural firing rates during various tasks including walking, reaching, and resting.

Main Results:

  • Neural firing rates were significantly tuned to behavior, supporting existing neuroscience findings.
  • Over 95% accuracy was achieved in classifying different behavioral tasks from neural data.
  • Decoding techniques proved viable despite environmental variations and distractions.

Conclusions:

  • Motor cortex activity robustly encodes complex behaviors in unconstrained settings.
  • Freely-moving experimental paradigms are valuable for advancing brain-computer interface research.
  • Findings support the potential utility of decoding neural signals for prosthetic control.