Physiological response of normal and RD mouse retinal ganglion cells to electrical stimulation

The epiretinal prosthesis aims to restore functional vision by stimulating electrically the retinal ganglion cells (RGCs) in patients afflicted with degenerative diseases that affect the photoreceptors, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). As degeneration progresses, photoreceptor death is followed by pronounced remodeling and rewiring of remaining inner retinal cells. Despite the loss of rods and cones, a considerable population of RGCs remain receptive to prosthetic stimulation. To stimulate effectively a localized population of RGCs, an improved understanding of the anatomical and physiological properties of these cells is required. Additionally, possible alterations in electrical excitability, produced by the effects of retinal degeneration, needs to be assessed. This study investigates the effect of RGC soma size on the threshold for action potential generation in normal and rd mice and its implications for the rescue of visual function.