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Updated: May 14, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
Published on: October 14, 2025
Computational modeling for assessment of IBD: to be or not to be?
Franciscus M Vos1, Jeroen A W Tielbeek, Robiel E Naziroglu
1Delft University of Technology, The Netherlands. f.m.vos@tudelft.nl
Abstract:
The grading of inflammatory bowel disease (IBD) severity is important to determine the proper treatment strategy and to quantify the response to treatment. Traditionally, ileocolonoscopy is considered the reference standard for assessment of IBD. However, the procedure is invasive and requires extensive bowel preparation. Magnetic resonance imaging (MRI) has become an important tool for determining the presence of disease activity. Unfortunately, only moderate interobserver agreement is reported for most of the radiological severity measures. There is a clear demand for automated evaluation of MR images in Crohn's disease (CD). This paper aims to introduce a preliminary suite of fundamental tools for assessment of CD severity. It involves procedures for image analysis, classification and visualization to predict the colonoscopy disease scores.
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