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NMR Spectrometers: Overview

NMR Spectrometers: Overview

NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...

NMR Spectroscopy of Aromatic Compounds

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Aromatic compounds can be identified or analyzed using proton NMR and carbon‐13 NMR. Typically, aromatic hydrogens or hydrogens directly bonded to the aromatic rings are strongly deshielded by the aromatic ring current. Therefore, they absorb in the range of 6.5–8.0 ppm in proton NMR spectra. For instance, aromatic hydrogens directly bonded to the benzene ring absorb at 7.3 ppm. However, aromatic hydrogens of larger rings absorb farther upfield or downfield than the ideal range. Consider...

Raman Spectroscopy Instrumentation: Overview

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A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
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Applications Of NMR In Biology

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Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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NMR Spectrometers: Resolution and Error Correction

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When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...

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Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
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Updated: May 14, 2026

A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy

A New Straightforward Method for Lipophilicity (logP) Measurement using ¹⁹F NMR Spectroscopy

Published on: January 30, 2019

A mobile NMR system with full spectroscopy capability.

Chao Ma¹, Zhi-Pei Liang

¹Department of Electrical and Computer Engineering and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 1406 West Green Street, Urbana, IL 61801, USA. chaoma2@illinois.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|February 1, 2013

Summary

This summary is machine-generated.

Researchers developed a portable nuclear magnetic resonance (NMR) system for spectroscopy. This mobile NMR device offers high-resolution analysis of small samples, enabling advanced chemical insights outside traditional lab settings.

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15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale

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Published on: April 19, 2021

Area of Science:

Analytical Chemistry
Spectroscopy
Instrumentation Science

Background:

Traditional Nuclear Magnetic Resonance (NMR) systems are typically large, complex, and require specialized laboratory environments.
The need for portable and accessible NMR technology is growing for field applications and point-of-care diagnostics.

Purpose of the Study:

To develop a compact and mobile Nuclear Magnetic Resonance (NMR) system with full spectroscopy capabilities.
To demonstrate the system's performance using small sample volumes and achieve high-resolution spectra.

Main Methods:

The system utilizes a portable 0.93 T permanent magnet.
A microcoil with a diameter of 550 µm and 8 turns was employed.
Compact electronic systems were integrated for signal processing and control.

Main Results:

The mobile NMR system achieved a spectrum linewidth of 0.4 parts per million.
A signal-to-noise ratio of 408 was obtained from a 37 nL water sample with 128 averages.
Representative proton ((1)H) and fluorine ((19)F) spectra were successfully acquired and presented.

Conclusions:

The developed mobile NMR system demonstrates the feasibility of high-performance spectroscopy in a portable format.
This technology has the potential to broaden the accessibility of NMR analysis for various scientific and industrial applications.
The system's performance metrics indicate its suitability for detailed chemical analysis of micro-scale samples.