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Updated: May 14, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
Published on: October 17, 2025
Using digital electronic design flow to create a Genetic Design Automation tool
Y Gendrault1, M Madec, V Wlotzko
1Institut d’Electronique du Solide et des Systèmes (InESS Institute of Electronics for Solids and Systems), Université de Strasbourg(Unistra) and the Centre National de Recherches Scientifiques (CNRS),UMR7163, Strasbourg, France. ygendrault@unistra.fr
Abstract:
Synthetic bio-systems become increasingly more complex and their development is lengthy and expensive. In the same way, in microelectronics, the design process of very complex circuits has benefited from many years of experience. It is now partly automated through Electronic Design Automation tools. Both areas present analogies that can be used to create a Genetic Design Automation tool inspired from EDA tools used in digital electronics. This tool would allow moving away from a totally manual design of bio-systems to assisted conception. This ambitious project is presented in this paper, with a deep focus on the tool that automatically generates models of bio-systems directly usable in electronic simulators.
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