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Updated: May 14, 2026

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
Published on: December 1, 2023
Heating characteristics with a re-entrant type applicator in consideration of tissue blood flow rate
1Graduate school of Mechanical Engineering, Meiji University, 1-1-1 Higashi-mita, Tama-ku, Kawasaki 214-8571, Japan. ce12010@meiji.ac.jp
Abstract:
We have proposed the heating system based on a re-entrant cavity that can heat a localized deep region in a living body noninvasively. This system is superior in a local heating characteristic. However, when the living body was treated as a heating object during thermotherapy (hyperthermia), the effect of blood flow changes on a heating characteristic has to be examined. The purpose of this study was to establish the quantitative evaluation method of heating characteristics for a re-entrant type applicator. The numerical analyses by using three-dimensional finite element method in consideration of a blood flow and fundamental experiments with prototype system were carried out. Since the difference of numerical analyses and experiments was as small as about 4.2 [%] by evaluation with full width at half maximum (FWHM), the validity of this numerical analysis was confirmed.
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