Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 14, 2026

Translational Rabbit Model of Chronic Cardiac Pacing

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

Percutaneously injectable fetal pacemaker: electronics, pacing thresholds, and power budget.

Adriana Nicholson¹, Ramen Chmait, Yaniv Bar-Cohen

¹Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA. nicholsa@usc.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|February 1, 2013

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Technical Success of Fetal Aortic Valvuloplasty in Relation to Center Volumes: A Report From the International Fetal Cardiac Intervention Registry.

Circulation. Cardiovascular interventions·2026

Same author

Describing Inconsistencies in Pediatric Labeling of Medical Devices.

JAMA network open·2025

Same author

Did Down-Regulated Instincts Enable Human Gene-Culture Coevolution?

Evolutionary anthropology·2025

Same author

Association between the oxidative balance score and testosterone deficiency in males: a cross-sectional study.

Frontiers in nutrition·2025

Same author

Artificial intelligence algorithm for real-time diagnostic assist in orofacial pain.

Journal of the American Dental Association (1939)·2025

Same author

Proceedings from The Consortium for Technology & Innovation in Pediatrics (CTIP) 2024 Annual Pediatric Device Innovation Symposium.

BMC proceedings·2025

This study details a miniaturized fetal pacemaker to treat fatal hydrops fetalis. The device prioritizes low power consumption and wireless recharging due to size constraints, addressing critical battery challenges.

Area of Science:

Biomedical Engineering
Fetal Medicine
Cardiology

Background:

Complete heart block in fetuses can lead to hydrops fetalis, a fatal condition.
Existing treatments are limited, necessitating innovative solutions for fetal cardiac conditions.

Purpose of the Study:

To develop a miniaturized percutaneous cardiac pacemaker for fetal implantation.
To address the technical challenges of battery life and wireless recharging in a 3mm device.

Main Methods:

Determined pacing thresholds for a relaxation oscillator using surface mount components.
Analyzed device power consumption across various electrode configurations and stimulus parameters.
Assessed the feasibility of an inductive recharging system within package constraints.

More Related Videos

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Published on: June 29, 2022

Related Experiment Videos

Last Updated: May 14, 2026

Translational Rabbit Model of Chronic Cardiac Pacing

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Published on: June 29, 2022

Main Results:

Established pacing thresholds for the designed oscillator circuit.
Identified power consumption characteristics relevant to device design.
Confirmed the feasibility of an inductive recharging system for the miniaturized pacemaker.

Conclusions:

A miniaturized pacemaker is feasible for treating fetal complete heart block and hydrops fetalis.
Low power design and wireless recharging are critical for device functionality.
The developed technology offers a potential life-saving intervention for affected fetuses.