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Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

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Related Experiment Video

Updated: May 14, 2026

Changing the Direction and Orientation of Electric Field During Electric Pulses Application Improves Plasmid Gene Transfer in vitro

Changing the Direction and Orientation of Electric Field During Electric Pulses Application Improves Plasmid Gene Transfer in vitro

Published on: September 12, 2011

An approach towards bronchoscopic-based gene therapy using electrical field accelerated plasmid droplets.

D Hradetzky¹, S Boehringer, Th Geiser

¹University of Applied Sciences and Arts Northwestern Switzerland, School of Life Sciences, Institute for Medical and Analytical Technologies, 4132 Muttenz, Switzerland. david.hradetzky@fhnw.ch

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|February 1, 2013

Summary

Gene therapy offers new hope for idiopathic pulmonary fibrosis (IPF) by restoring lung self-healing. A novel device delivers therapeutic genes to the distal lung epithelium, overcoming cellular barriers for potential IPF treatment.

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Last Updated: May 14, 2026

Changing the Direction and Orientation of Electric Field During Electric Pulses Application Improves Plasmid Gene Transfer in vitro

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Published on: September 12, 2011

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Area of Science:

Pulmonary Medicine
Biotechnology
Medical Devices

Background:

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by impaired alveolar epithelial repair.
Current therapeutic options for IPF are limited, necessitating novel treatment strategies.
Gene therapy holds promise for restoring lung self-healing mechanisms in IPF.

Purpose of the Study:

To develop a novel therapeutic instrument for gene delivery to the distal lung epithelium.
To investigate the feasibility of using an electrical field for gene transduction in lung tissue.
To create a device compatible with minimally invasive procedures like bronchoscopy.

Main Methods:

Concept development and experimental validation of an electrical field-based gene delivery device.
Utilizing charged plasmid droplets accelerated towards lung tissue.
Assessing the device's ability to overcome cell membranes via impact energy.

Main Results:

Demonstrated the concept of an electrical field-driven gene delivery system.
Presented initial experimental data supporting the device's functionality.
Showcased the potential for gene transduction in the distal lung epithelium.

Conclusions:

The developed device shows potential for effective gene delivery to the distal lung.
This technology could enable gene therapy for IPF by targeting alveolar epithelial cells.
Integration into bronchoscopy offers a minimally invasive approach for future IPF treatments.