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A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

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A wirelessly programmable chip for multi-channel neural stimulation.

Songping Mai¹, Zhijun Wang, Chun Zhang

¹Lab of Integrated Circuits and Systems Design, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. mai.songping@sz.tsinghua.edu.cn

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|February 1, 2013

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This study introduces an implantable chip for neural stimulation, wirelessly programmable for precise control. It offers efficient, low-power performance with 16 channels, ideal for advanced neuromodulation applications.

Area of Science:

Biomedical Engineering
Electrical Engineering
Neuroscience

Background:

Neural stimulation requires sophisticated implantable devices for therapeutic applications.
Existing devices often face limitations in programmability, power efficiency, and channel count.

Purpose of the Study:

To develop an implantable, wirelessly controlled mixed-signal chip for neural stimulation.
To enhance device functionality with programmable parameters and ensure charge balance for safety.

Main Methods:

Implementation of a 16-channel, inductively powered mixed-signal chip using 0.35-µm high-voltage CMOS technology.
Wireless programmability of stimulating pulse frequency, amplitude, and width.
Utilization of a flexible switch array for charge balance and a dual-voltage-source scheme for power reduction.

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Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

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Published on: March 3, 2023

Main Results:

The chip supports 16 stimulating channels with a maximum rate of 15Kbps.
All stimulation parameters are wirelessly programmable.
The device achieves low power consumption, drawing less than 1mA under typical operating conditions.
Guaranteed charge balance through a flexible switch array.

Conclusions:

The developed chip offers a versatile and efficient solution for neural stimulation.
Wireless programmability and low power consumption make it suitable for advanced neuromodulation.
The design ensures safe and effective neural interfacing.