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Cardiovascular genomics.

Shu-Fen Wung1, Kathleen T Hickey, Jacquelyn Y Taylor

  • 1The University of Arizona, Tucson, AZ, USA. shufen@nursing.arizona.edu

Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing
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Summary
This summary is machine-generated.

Cardiovascular genomics is advancing, but clinical genetic tests for common diseases like heart attack and stroke are limited. However, genetic testing is recommended for specific inherited heart conditions such as long QT syndrome and hypertrophic cardiomyopathy.

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Area of Science:

  • Cardiovascular Genomics
  • Clinical Genetics
  • Genomic Medicine

Background:

  • Cardiovascular genomics research is rapidly evolving, impacting clinical practice.
  • Understanding genetic contributions to cardiovascular diseases (CVD) is crucial.
  • Key areas include myocardial infarction (MI), coronary artery disease (CAD), stroke, and sudden cardiac death (SCD).

Purpose of the Study:

  • To provide an update on cardiovascular genomics.
  • To highlight recent advances in genomic research, testing, and clinical implications.
  • To focus on three clinically relevant exemplars: MI/CAD, stroke, and SCD.

Main Methods:

  • A review and summary of recent salient literature by genomic nurse experts.
  • Focus on updates for three selected cardiovascular genomic conditions.

Main Results:

  • Ongoing research aims to identify comprehensive genetic markers for common CVDs like MI and stroke.
  • Genomic technologies are increasingly adopted in clinical settings.
  • Clinical application is notable in patients at risk for SCD due to conditions like long QT syndrome (LQTS) and hypertrophic cardiomyopathy (HCM).

Conclusions:

  • Clinically recommended genetic tests are not yet available for many common CVDs.
  • Direct-to-consumer genetic tests are being marketed, necessitating careful consideration.
  • Genetic testing is clinically recommended for specific single-gene disorders like LQTS and HCM.
  • Nurses are vital in cardiogenetics, requiring understanding of genomic developments to translate knowledge into practice.