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Serum irisin levels in new-onset type 2 diabetes
Yeon-Kyung Choi1, Mi-Kyung Kim, Kwi Hyun Bae
1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea.
Diabetes Research and Clinical Practice
|February 2, 2013
Summary
Serum irisin levels are lower in type 2 diabetes (T2D) patients. Lower irisin is linked to increased odds of newly diagnosed T2D, suggesting a role in glucose intolerance.
Area of Science:
- Endocrinology
- Metabolic Research
- Adipose Tissue Biology
Background:
- Irisin, a myokine, promotes browning of white adipose tissue.
- Its role in type 2 diabetes (T2D) remains under investigation.
Purpose of the Study:
- To compare serum irisin levels in T2D patients versus normal glucose tolerance (NGT) controls.
- To assess the association between irisin and metabolic parameters in T2D.
Main Methods:
- Cross-sectional study of 104 T2D and 104 NGT subjects.
- Measurement of serum irisin, adiponectin, and metabolic parameters.
- Multivariate logistic and multiple regression analyses.
Main Results:
- Significantly lower serum irisin in T2D vs. NGT groups (p=0.003).
- Increased irisin associated with reduced odds of newly diagnosed T2D (OR 0.64, p=0.006).
- 2h plasma glucose independently influenced irisin levels (p=0.004).
Conclusions:
- Serum irisin levels are decreased in T2D patients.
- Irisin is inversely associated with newly diagnosed T2D.
- Irisin may play a role in glucose intolerance and T2D pathogenesis.
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