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Circulating cathepsin K as a potential novel biomarker of coronary artery disease

Xian Wu Cheng1, Ryosuke Kikuchi, Hideki Ishii

  • 1Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. xianwu@med.nagoya-u.ac.jp

Atherosclerosis
|February 2, 2013
PubMed

Insights

Elevated levels of Cathepsin K (CatK) are closely associated with coronary artery disease (CAD). CatK is a potent collagenase and a novel biomarker for detecting CAD presence.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Biomarker Discovery

Background:

  • Cathepsin K (CatK) is a potent mammalian collagenase implicated in atherosclerosis.
  • Its role in coronary artery disease (CAD) prevalence requires investigation.

Purpose of the Study:

  • To investigate the association between circulating Cathepsin K (CatK) levels and the prevalence of coronary artery disease (CAD).

Main Methods:

  • Plasma CatK, I-PINP, and ICTP levels were measured in 252 CAD patients and 132 controls.
  • Coronary angiography and intravascular ultrasound were performed.
  • Statistical analyses included linear and logistic regression.

Main Results:

  • CAD patients exhibited significantly higher CatK levels and ICTP/I-PINP ratios compared to controls.
  • CatK levels positively correlated with ICTP/I-PINP ratios and plaque volume.
  • CatK was an independent predictor of CAD and correlated inversely with fibrous volume.

Conclusions:

  • High circulating CatK levels are closely linked to the presence of CAD.
  • Cathepsin K emerges as a novel and significant biomarker for coronary artery disease.
Abstract

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