Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-density lipoprotein cholesterol and longevity.

M Nikkilä1, J Heikkinen

  • 1Department of Clinical Sciences, University of Tampere, Finland.

Age and Ageing
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pesticide residues in boreal arable soils: Countrywide study of occurrence and risks.

Environmental pollution (Barking, Essex : 1987)·2024
Same author

Long-term life satisfaction in ageing women with work disability due to mental and musculoskeletal disorders.

Maturitas·2023
Same author

Early prognosticators of later TSPO-PET-measurable microglial activation in multiple sclerosis.

Multiple sclerosis and related disorders·2023
Same author

Knowledge, Attitudes, and Practices of Finnish Dairy Farmers on Cryptosporidiosis.

Journal of agromedicine·2022
Same author

MRI Findings in Acute Tonsillar Infections.

AJNR. American journal of neuroradiology·2021
Same author

Comorbidity of mental and musculoskeletal disorders in ageing women: A data linkage study using national registries.

Maturitas·2021
Same journal

How social, psychological, and spiritual needs are supported in the last months of life: evidence from the English Longitudinal Study of Ageing end-of-life interviews.

Age and ageing·2026
Same journal

Are there sex differences in the influence of insomnia symptoms and sleep duration on the trajectory of neuromuscular strength decline?

Age and ageing·2026
Same journal

Factors associated with mortality in older sepsis patients: a nationwide retrospective cohort study in Germany.

Age and ageing·2026
Same journal

Frailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial.

Age and ageing·2026
Same journal

Overlapping premorbid frailty, multimorbidity and malnutrition and their associations with poor outcomes in patients with stroke.

Age and ageing·2026
Same journal

Overall and cause-specific mortality and associated risk factors among middle-aged and older South Africans: findings from the health and ageing in Africa: a longitudinal study of an INDEPTH community in rural South Africa (HAALSI).

Age and ageing·2026
See all related articles

Elderly individuals exhibit higher high-density lipoprotein (HDL) cholesterol levels compared to younger adults and those with triple-vessel disease. This finding highlights the protective role of HDL cholesterol in aging and cardiovascular health.

Area of Science:

  • Cardiology
  • Gerontology
  • Lipid Metabolism

Background:

  • Serum lipid profiles, including total cholesterol, HDL cholesterol, and triglycerides, are critical indicators of cardiovascular health.
  • Age-related changes in lipid metabolism and their association with cardiovascular disease (CVD) risk require further investigation.
  • Understanding lipid profiles in diverse age groups and disease states is essential for risk stratification and management.

Purpose of the Study:

  • To compare serum lipid profiles (total cholesterol, HDL cholesterol, triglycerides) across three distinct groups: healthy elderly individuals, younger adults without coronary artery disease (CAD), and patients with established triple-vessel disease.
  • To investigate the prevalence of dyslipidemia in these groups and identify significant differences in lipid parameters.
  • To assess the relationship between lipid levels, particularly HDL cholesterol, and the presence of severe coronary artery disease.

Related Experiment Videos

Main Methods:

  • Cross-sectional study design comparing three participant groups: healthy elderly (85-89 years), younger adults without CAD (38-62 years), and patients with triple-vessel disease (32-69 years).
  • Serum levels of total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides were measured.
  • Coronary artery disease severity was determined by coronary angiography in the patient groups.

Main Results:

  • Patients with triple-vessel disease exhibited significantly higher mean total cholesterol compared to those without CAD and the elderly group.
  • While total cholesterol levels above 6.5 mmol/l showed a trend towards higher prevalence in the triple-vessel disease group, the difference was not statistically significant.
  • HDL cholesterol and the HDL/total cholesterol ratio were significantly higher in the elderly group compared to both the younger adults without CAD and the triple-vessel disease patients.
  • A high serum HDL cholesterol level (>1.0 mmol/l) was observed in 92% of the elderly, 69% of patients without CAD, and 46% of patients with triple-vessel disease, with significant differences between all groups.

Conclusions:

  • The elderly population demonstrates a favorable lipid profile characterized by significantly higher high-density lipoprotein (HDL) cholesterol levels.
  • Elevated HDL cholesterol in the elderly may contribute to their potentially lower risk or delayed onset of severe coronary artery disease despite age.
  • These findings underscore the importance of HDL cholesterol as a protective factor against cardiovascular disease, even in advanced age.