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Updated: May 14, 2026

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
Subcutaneous and perineural botulinum toxin type a for neuropathic pain: a descriptive review
Gustavo Fabregat1, José De Andrés, Vicente L Villanueva-Pérez
1*Multidisciplinary Pain Management Department †Critical Care and Multidisciplinary Pain Management Department, School of Medicine of Valencia, General University Hospital, Valencia, Spain.
Objective:
Botulinum toxin is a neurotoxin that has been widely used in chronic pain for the treatment of multiple conditions with a component of localized muscle spasm. Recent studies suggest that botulinum toxin is effective in the treatment of neuropathic pain syndromes such as postherpetic neuralgia or painful scars.
Methods:
We searched the PubMed and OvidSP databases. We also included cross-referencing bibliographies from primary and review articles.
Discussion:
In this descriptive review, we evaluate the usefulness, safety, and potential pathophysiological mechanism of botulinum toxin type A for treatment of painful disorders with neuropathic component such as postherpetic neuralgia, diabetic neuropathy, or trigeminal neuralgia.
Conclusions:
On the basis of the analysis of the reports published in the literature, it would seem that fractioned peripheral subcutaneous and perineural injections of botulinum toxin type A may be useful for the treatment of various chronic pain conditions with neuropathic component.
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