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Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

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Reduced lateralization in early onset schizophrenia.

Martin T Freitag¹, Thomas van Bruggen, Klaus H Fritzsche

¹Quantitative Imaging Based Disease Characterization, DKFZ, Heidelberg, Germany.

Neuroscience Letters

|February 2, 2013

Summary

Schizophrenia patients show reduced white matter integrity in the corpus callosum and optic radiation. Altered lateralization in visual and cerebellar pathways suggests a role in schizophrenia pathogenesis.

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Area of Science:

Neuroimaging
Neuroscience
Psychiatry

Background:

Schizophrenia is associated with gray and white matter abnormalities in specific brain regions.
Previous studies identified alterations in the cerebellum, visual system, and corpus callosum.

Purpose of the Study:

To investigate white matter alterations in schizophrenia using tract-based spatial statistics (TBSS).
To examine changes in the lateralization of the optic radiation and superior cerebellar peduncle.

Main Methods:

Diffusion tensor imaging (DTI) was performed on 12 first-admission schizophrenia patients and age-matched healthy controls.
Tract-based spatial statistics (TBSS) was used for preprocessing and regional analysis of fractional anisotropy (FA).
Analysis focused on the corpus callosum, optic radiation, and cerebellar peduncles.

Main Results:

Significant reduction in fractional anisotropy (FA) was observed in the corpus callosum and optic radiation of patients.
No significant FA differences were found in the middle and superior cerebellar peduncles.
Schizophrenia patients exhibited decreased lateralization of the optic radiation and superior cerebellar peduncles.

Conclusions:

Findings support schizophrenia as a neurodevelopmental disorder.
Altered white matter lateralization may be crucial in the pathogenesis of schizophrenia.