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Related Experiment Video

Updated: May 14, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Lessons to be learned from periodontitis.

Koen M J Janssen¹, Arjan Vissink, Menke J de Smit

¹Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Current Opinion in Rheumatology

|February 2, 2013

Summary

This summary is machine-generated.

Periodontitis and rheumatoid arthritis (RA) share genetic and immune pathways. The bacterium Porphyromonas gingivalis may link these conditions through protein citrullination, suggesting periodontal treatment could impact RA severity.

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Published on: February 17, 2023

Area of Science:

Immunology
Periodontology
Rheumatology

Background:

Periodontitis and rheumatoid arthritis (RA) are chronic inflammatory diseases.
Both conditions exhibit shared genetic risk factors and immunopathogenesis.
The role of oral pathogens in systemic inflammation is an area of active research.

Purpose of the Study:

To review the link between periodontitis and rheumatoid arthritis (RA).
To explore shared genetic risk factors and immunopathogenesis.
To investigate the potential role of Porphyromonas gingivalis in RA etiology.

Main Methods:

Literature review focusing on genetic factors, immunopathogenesis, and P. gingivalis.
Analysis of studies examining citrullination and its role in both diseases.
Review of findings from periodontal treatment studies in RA patients.

Main Results:

Porphyromonas gingivalis possesses a peptidyl arginine deiminase (PAD) enzyme crucial for citrullination.
Citrullinated proteins and PAD enzymes are present in periodontal tissues.
Anticitrullinated protein antibodies (ACPAs) are found in gingival crevicular fluid.
Periodontal treatment has been associated with reduced RA severity.

Conclusions:

Periodontitis and RA share similarities in immune responses and tissue degradation.
Common environmental and genetic risk factors link periodontitis and RA.
Citrullination by human and P. gingivalis PAD enzymes establishes a connection between the two diseases.