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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

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Related Experiment Video

Updated: May 14, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

New insights into prostate cancer stem cells.

Xin Chen1, Kiera Rycaj, Xin Liu

  • 1Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, TX, USA.

Cell Cycle (Georgetown, Tex.)
|February 2, 2013
PubMed
Summary

Prostate cancer stem cells (PCSCs) are key to understanding tumor growth and resistance to treatment. Research into PCSCs offers potential for new therapies against advanced prostate cancer.

Keywords:
cancer stem cellsdifferentiationprostate cancerprostate cancer stem cellstherapy resistance

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Last Updated: May 14, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Area of Science:

  • Oncology
  • Cancer Stem Cell Biology

Background:

  • Prostate cancer (PCa) is a leading cause of cancer-related death in men.
  • The origins and progression mechanisms of PCa, particularly castration-resistant PCa, are not fully understood.
  • Cancer stem cells (CSCs) are implicated in tumor initiation, metastasis, and therapeutic resistance across various cancers.

Purpose of the Study:

  • To review current knowledge on normal prostate stem/progenitor cells.
  • To highlight recent advancements in understanding prostate cancer stem cells (PCSCs).
  • To discuss the potential cell-of-origin for PCa and the role of PCSCs in disease progression and castration resistance.

Main Methods:

  • Literature review and synthesis of existing research on prostate stem cells and PCSCs.
  • Analysis of experimental strategies used to identify and characterize PCSCs.
  • Discussion of the implications of PCSC biology for PCa etiology and treatment resistance.

Main Results:

  • Prostate cancer stem cells (PCSCs) have been identified in various model systems.
  • PCSCs are hypothesized to play a role in PCa initiation, progression, metastasis, and therapy resistance.
  • Understanding PCSC properties is crucial for deciphering PCa biology.

Conclusions:

  • PCSCs are likely involved in the progression of prostate cancer, including the development of castration resistance.
  • Further elucidation of PCSC characteristics and regulatory mechanisms is essential.
  • Targeting PCSCs may offer novel therapeutic strategies for castration-resistant prostate cancer.