Learning and survival memory undergoing a permanent bilateral carotid ligation in rats
Maria Cecília Santos Cavalcanti Melo1, Diego Gadelha, Guilherme Veras Mascena
1Department of Ophthalmology, FCM, Campina Grande, PB, Brazil.
Purpose:
To evaluate the effect of cerebral hypoxia-ischemia on memory and learning survival of rats submitted to permanent bilateral carotid ligation (PBCL).
Methods:
Twenty-four survivors of PBCL were evaluated after 30 days with regard to memory and learning using a water survival maze. Twenty-three healthy rats were used as control group. The results were expressed by their means and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee for animal investigation.
Results:
The mortality rate for the surgery was 44.4%. The latency time to find the survival platform was higher in rats that underwent PBCL (Normal: 10.24 ± 1.85s -
Study:
25.30 ± 4.69s - Mann - Whitney p=0.0388). Additionally, the type of swimming and the spatial stability of the studied rats on the survival platform were compromised in these animals.
Conclusion:
The permanent bilateral carotid ligation induces change in the learning and survival memory.