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(-)-Hydroxycitrate and conditioned aversions.

J Panksepp, A Pollack, R B Meeker

    Pharmacology, Biochemistry, and Behavior
    |June 1, 1977
    PubMed
    Summary
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    (-)-hydroxycitrate salts can condition taste aversion in rats. The ethylenediamine salt showed strong rejection, while the sodium salt

    Area of Science:

    • Pharmacology
    • Behavioral Neuroscience
    • Physiology

    Background:

    • (-)-hydroxycitrate is a compound found in Garcinia cambogia.
    • Its effects on appetite and conditioned taste aversion are not fully understood.
    • Previous research suggests potential appetite-suppressing qualities.

    Purpose of the Study:

    • To investigate the ability of different salts of (-)-hydroxycitrate to induce conditioned rejection of a saccharin solution.
    • To compare the effectiveness of (-)-hydroxycitrate salts with lithium chloride.
    • To determine if food intake reduction is a direct consequence of aversive effects.

    Main Methods:

    • Rats were administered various salts of (-)-hydroxycitrate.
    • Conditioned taste aversion was established using a 0.25% saccharin solution.

    Related Experiment Videos

  • Food intake was monitored following drug administration.
  • Deprivation and nondeprivation conditions were employed.

    • Main Results:

    • The ethylenediamine salt of (-)-hydroxycitrate induced significant conditioned rejection of saccharin.
    • This effect was less potent than equimolar lithium chloride.
    • The sodium salt induced rejection only in nondeprived rats.
    • Food intake reduction was transient, occurring only in the first hour post-administration.
    • Appetite reduction magnitude did not correlate with conditioned rejection.

    Conclusions:

    • (-)-hydroxycitrate salts, particularly the ethylenediamine salt, can produce conditioned taste aversion.
    • The observed food intake reduction is likely not solely due to aversive drug effects.
    • Further research is warranted to elucidate the mechanisms of (-)-hydroxycitrate's effects on appetite and behavior.