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Phasic volumetric coronary venous outflow patterns in conscious dogs
1Department of Medicine, State University of New York, Buffalo School of Medicine.
The American Journal of Physiology
|May 11, 1990
Summary
Phasic venous outflow in conscious dogs reveals distinct coronary sinus and great cardiac vein patterns. Adenosine vasodilation shifts these patterns towards systole, suggesting venous compliance influences flow dynamics.
Area of Science:
- Cardiovascular Physiology
- Hemodynamics
Background:
- Understanding coronary venous outflow patterns is crucial for interpreting cardiac function.
- Previous studies in anesthetized animals showed different venous flow dynamics.
Purpose of the Study:
- To characterize phasic venous outflow patterns in the coronary sinus and great cardiac vein of conscious dogs.
- To investigate the impact of vasodilation on these venous flow patterns.
Main Methods:
- Utilized implantable ultrasonic transit-time flow probes in chronically instrumented conscious dogs.
- Measured volumetric venous outflow from the coronary sinus (n=9) and great cardiac vein (n=5).
- Administered adenosine to induce vasodilation and observed changes in flow patterns.
Main Results:
- Great cardiac vein flow was predominantly systolic at rest (61%), while coronary sinus flow was diastolic (64%).
- Adenosine vasodilation shifted both to predominantly systolic flow (coronary sinus: 58%, great cardiac vein: 75%).
- Peak venous flow timing shifted from end-systole to mid-systole post-vasodilation.
Conclusions:
- Coronary venous outflow patterns are influenced by venous compliance between different vessels.
- Resting coronary sinus flow patterns in conscious dogs differ from those in anesthetized animals, possibly due to anesthesia or surgical manipulation.