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Related Concept Videos

Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: May 14, 2026

Generation of Induced Pluripotent Stem Cells from Human Peripheral T Cells Using Sendai Virus in Feeder-free Conditions
09:32

Generation of Induced Pluripotent Stem Cells from Human Peripheral T Cells Using Sendai Virus in Feeder-free Conditions

Published on: November 11, 2015

Steps toward safe cell therapy using induced pluripotent stem cells.

Hideyuki Okano1, Masaya Nakamura, Kenji Yoshida

  • 1Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan. hidokano@a2.keio.jp

Circulation Research
|February 2, 2013
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem cells (iPSCs) offer promise for regenerative medicine but face safety challenges. This review examines iPSC advancements and future directions for safe cell therapies, focusing on central nervous system and cardiovascular repair.

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Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus
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Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus

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Derivation and Characterization of a Transgene-free Human Induced Pluripotent Stem Cell Line and Conversion into Defined Clinical-grade Conditions
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Derivation and Characterization of a Transgene-free Human Induced Pluripotent Stem Cell Line and Conversion into Defined Clinical-grade Conditions

Published on: November 26, 2014

Related Experiment Videos

Last Updated: May 14, 2026

Generation of Induced Pluripotent Stem Cells from Human Peripheral T Cells Using Sendai Virus in Feeder-free Conditions
09:32

Generation of Induced Pluripotent Stem Cells from Human Peripheral T Cells Using Sendai Virus in Feeder-free Conditions

Published on: November 11, 2015

Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus
09:43

Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus

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Derivation and Characterization of a Transgene-free Human Induced Pluripotent Stem Cell Line and Conversion into Defined Clinical-grade Conditions
10:48

Derivation and Characterization of a Transgene-free Human Induced Pluripotent Stem Cell Line and Conversion into Defined Clinical-grade Conditions

Published on: November 26, 2014

Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Biomedical sciences

Background:

  • Patient-specific human embryonic stem cells face ethical and technical hurdles.
  • Induced pluripotent stem cells (iPSCs) are generated by reprogramming somatic cells with transcription factors.
  • iPSCs hold significant potential for regenerative medicine and disease modeling.

Purpose of the Study:

  • To review recent achievements in safe iPSC-based cell therapy.
  • To discuss future tasks for ensuring iPSC safety.
  • To use central nervous system (CNS) and cardiovascular repair as models.

Main Methods:

  • Review of current literature on iPSC technology and safety.
  • Analysis of preclinical data for iPSC efficacy and safety.
  • Focus on iPSC applications in CNS and cardiovascular repair.

Main Results:

  • iPSC technology presents opportunities but also risks like genetic abnormalities and tumorigenicity.
  • Preclinical data supporting iPSC safety and efficacy are growing.
  • Regenerative medicine strategies using iPSCs show promise for CNS and cardiovascular repair.

Conclusions:

  • Addressing safety concerns is crucial for the clinical translation of iPSC-based therapies.
  • Continued research and preclinical validation are essential for safe and effective iPSC applications.
  • iPSCs represent a promising avenue for treating CNS and cardiovascular diseases.