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Related Concept Videos

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Development of the Oral Microbiota01:28

Development of the Oral Microbiota

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Related Experiment Video

Updated: May 14, 2026

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

A randomized controlled trial comparing two different antibiotic regimens for prophylaxis at cesarean section.

Gourisankar Kamilya1, Subrata Lall Seal, Joydev Mukherji

  • 1Department of Obstetrics & Gynaecology, R. G. Kar Medical College, 1, Khudiram Bose Sarani, Kolkata, 700 004 India ; Bb-11/G, Salt Lake, Sector-I, Kolkata, 700 064 West Bengal India.

Journal of Obstetrics and Gynaecology of India
|February 2, 2013
PubMed
Summary

Cefotaxime, a less expensive antibiotic, is as effective as amoxicillin-clavulanic acid for preventing infections during cesarean sections. This study suggests preferring cefotaxime due to its comparable efficacy and lower cost.

Keywords:
AntibioticCesarean sectionProphylaxis

Related Experiment Videos

Last Updated: May 14, 2026

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Disease Prevention
  • Pharmacoeconomics

Background:

  • Cesarean section prophylaxis aims to prevent surgical site infections.
  • Amoxicillin-clavulanic acid is a commonly used, but more expensive, prophylactic agent.
  • Cefotaxime offers a narrower spectrum and lower cost alternative.

Purpose of the Study:

  • To compare the efficacy of cefotaxime versus amoxicillin-clavulanic acid for cesarean section prophylaxis.
  • To evaluate infectious morbidity and hospital stay between the two antibiotic groups.
  • To determine the cost-effectiveness of cefotaxime in this setting.

Main Methods:

  • A double-blind, randomized controlled trial involving 760 participants.
  • Two parallel treatment groups received either cefotaxime or amoxicillin-clavulanic acid.
  • Statistical analysis included Student's t test, Mann-Whitney U test, Chi-squared, and Fisher's exact tests.

Main Results:

  • Cefotaxime demonstrated comparable efficacy to amoxicillin-clavulanic acid.
  • No significant differences were observed in infectious morbidity (p=0.27 elective, p=0.11 emergency).
  • Hospital stay did not significantly differ between the groups.

Conclusions:

  • Cefotaxime is a cost-effective and equally effective alternative for cesarean section prophylaxis.
  • Healthcare providers should consider cefotaxime over more expensive amoxicillin-clavulanic acid.
  • This finding supports the use of narrower-spectrum, lower-cost antibiotics when appropriate.