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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: May 14, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

miRNA-mediated deregulation in leukemia.

Carmela Dell'aversana1, Lucia Altucci

  • 1Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche Naples, Italy ; Department of General Pathology, Second University of Naples Naples, Italy.

Frontiers in Genetics
|February 2, 2013
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) regulate gene expression and are implicated in cancer. Aberrant miRNA pathways contribute to leukemogenesis, acting as tumor suppressors or oncogenes.

Keywords:
hematopoiesisleukemiamicroRNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
  • They control crucial cellular processes like development, differentiation, and metabolism.
  • Dysregulated miRNAs are linked to various pathologies, including cancer.

Purpose of the Study:

  • To provide an overview of miRNA aberrations in leukemogenesis.
  • To discuss the role of miRNAs as tumor suppressors and oncogenes in blood cancers.
  • To summarize current understanding of altered miRNA biogenesis, activity, and control in leukemia.

Main Methods:

  • Literature review and synthesis of current research on miRNAs in leukemia.
  • Analysis of miRNA biogenesis, function, and deregulation in the context of cancer.
  • Review of studies investigating miRNA roles as tumor suppressors and oncogenes.

Main Results:

  • MicroRNA deregulation is a significant factor in the development of leukemia.
  • Aberrant miRNAs can function as either tumor suppressors or oncogenes (TSG/OG) in hematological malignancies.
  • Alterations in miRNA biogenesis, activity, and post-transcriptional regulation are key to leukemogenesis.

Conclusions:

  • MicroRNAs play a critical role in the initiation and progression of leukemia.
  • Targeting miRNA pathways presents potential therapeutic strategies for hematological cancers.
  • Further research into miRNA aberrations is crucial for understanding and treating leukemia.