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Lung ossification: an orphan disease.

Maria Konoglou¹, Paul Zarogoulidis, Aggeliki Baliaka

¹Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece;

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Summary

Diffuse pulmonary ossification (DPO), a rare lung condition, involves bone formation in lung tissue. This case highlights DPO as a potential cause of persistent pneumothorax, often misdiagnosed as interstitial lung disease.

Keywords:

Pulmonary nodules nodular disease ossification

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Area of Science:

Pulmonary Medicine
Pathology

Background:

Diffuse pulmonary ossification (DPO) is a rare condition characterized by metaplastic bone formation within the lung parenchyma.
It is often asymptomatic and typically diagnosed post-mortem, making its clinical recognition challenging.

Observation:

The case involves a patient presenting with persistent pneumothorax, a condition where air leaks into the space between the lung and chest wall.
Investigations were conducted to determine the underlying cause of the recurrent pneumothorax.

Findings:

The diagnostic workup revealed diffuse pulmonary ossification as the cause of the patient's persistent pneumothorax.
DPO can manifest with varied pulmonary lesions, potentially leading to misdiagnosis as interstitial lung diseases.

Implications:

This case underscores the importance of considering DPO in the differential diagnosis of persistent pneumothorax, especially when other causes are not apparent.
Recognizing DPO can potentially alter patient management and improve diagnostic accuracy for rare pulmonary conditions.