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Updated: May 14, 2026

Monitoring the Mechanical Evolution of Tissue During Neural Tube Closure of Chick Embryo
Published on: November 10, 2023
Multiple neural tube defects in a child: A rare developmental anomaly
Neha Singh1, Deepak Kumar Singh, Pallavi Aga
1Department of Radiodiagnosis, Chhatrapati Sahuji Maharaj Medical University (CSMMU), Lucknow, Uttar Pradesh, India.
Background:
The presence of multiple neural tube defects (NTDs) is a rare entity. Published literature shows not more than 10 case reports. Such cases contradict the well-established "zipper model" of neural tube closure and support "multi-site closure model."
Case Description:
We are reporting a unique case of multiple NTDs in a 5-month-o ld female child. Occipital encephalocele, dorsal meningomyelocele, Split cord malformation (SCM), and tethered cord were present in this case.
Conclusion:
This case report further substantiate the "multisite closure model," however, more research work on human neuro-embryology is needed to overcome the controversies of neural tube closure.
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