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Related Experiment Video

Updated: May 14, 2026

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
06:14

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

Treatment modalities and evaluation models for periodontitis.

Mohammad Tariq1, Zeenat Iqbal, Javed Ali

  • 1Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India.

International Journal of Pharmaceutical Investigation
|February 2, 2013
PubMed
Summary

Periodontitis, a common gum disease, involves inflammation and bone loss. This review explores non-surgical treatments, focusing on locally delivered antimicrobials and anti-inflammatories for better periodontal health.

Keywords:
Chemotherapeutic agentsintra-pocket devicesmechanical therapiesoral hygiene

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Published on: May 9, 2022

Related Experiment Videos

Last Updated: May 14, 2026

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
06:14

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Area of Science:

  • Dentistry
  • Periodontology
  • Pharmacology

Background:

  • Periodontitis is a prevalent inflammatory dental disease causing gum inflammation, periodontal ligament degeneration, and alveolar bone loss.
  • Effective management of periodontal infections is crucial for overall oral health.

Purpose of the Study:

  • To review current and emerging non-surgical treatment modalities for periodontitis.
  • To discuss locally delivered antimicrobial and anti-inflammatory medications for periodontal infections.
  • To explore in vitro and in vivo models for evaluating treatment efficacy.

Main Methods:

  • Review of preventive and treatment strategies for periodontitis.
  • Discussion of locally delivered antimicrobial and anti-inflammatory agents.
  • Analysis of in vitro dissolution models and microbiological strains.
  • Examination of animal models for periodontitis research.

Main Results:

  • Non-surgical management includes oral hygiene, mechanical instrumentation, and antimicrobial therapies.
  • Sustained-release intra-pocket systems represent a novel therapeutic approach.
  • Various medications are available or under FDA review for local delivery.
  • In vitro and animal models aid in predicting treatment performance.

Conclusions:

  • Locally delivered medications offer a promising strategy for managing periodontitis.
  • Further research into sustained-release systems and advanced models is warranted.
  • Comprehensive treatment approaches are essential for combating periodontal disease.