Related Experiment Video
Updated: May 14, 2026

Limited Bedding and Nesting as a Model for Early-Life Adversity in Mice
Published on: July 12, 2024
[Epigenetics of early interactions, depression and schizophrenia]
1Département de Psychiatrie, Hôpital Erasme, Bruxelles. pauline.monhonval@erasme.ulb.ac.be
Abstract:
Epigenetics is the study of the variations of genetic expression that occur not because of differences in DNA structure, but because of chromatin alternations that modulate DNA transcription. The mechanisms of epigenetics are thus the link between genome and phenotype. This article will explore the best known epigenetic mechanisms, namely DNA methylation and histone modifications and how they may lead to the emergence of depression and schizophrenia. The practical interest of this research is an understanding of the role of early interactions in the development of mental illness. Hopefully this understanding will lead to therapeutic pathways aimed at neutralizing these unfavourable epigenetic influences, with the ultimate goal of prevention of mental illness.
Related Concept Videos
Psychological and Sociocultural Causes of Schizophrenia
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Causes of Social Behavior III: Biological and Environmental Influences
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
