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Updated: May 14, 2026
12:27
A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
[Sphingosine-1-phosphate--molecular maestro]
Daria Salata1, Marta Budkowska, Barbara Dołegowska
1Katedra Diagnostyki Laboratoryjnej i Medycyny Molekularnej, Pomorski Uniwersytet Medyczny, Szczecin. daria_salata@wp.pl
Postepy Biochemii
|February 5, 2013
Summary
Sphingosine-1-phosphate (S1P), a lipid mediator, influences stem cell release from bone marrow. This finding highlights S1P
Area of Science:
- Lipid signaling
- Cell biology
- Biochemistry
Context:
- Sphingosine-1-phosphate (S1P) is a bioactive lipid synthesized by platelets and stored in erythrocytes.
- S1P exerts cellular effects via specific receptors (S1P1-S1P5) on cells like hematopoietic and nervous cells.
- It plays roles in cell migration, adhesion, differentiation, survival, inflammation, angiogenesis, and wound healing.
Purpose:
- To investigate the role of Sphingosine-1-phosphate (S1P) in stem cell mobilization.
- To explore S1P as a potential chemotactic factor for stem cells.
Summary:
- Sphingosine-1-phosphate (S1P) counteracts apoptosis, unlike sphingosine and ceramide.
- Recent research indicates S1P is a key factor in releasing stem cells from bone marrow into peripheral blood.
- Factors like tissue damage, stress, exercise, and certain drugs affect stem cell numbers.
Impact:
- Understanding S1P's role in stem cell release could advance regenerative medicine.
- S1P's function as a stem cell chemotactic factor offers new therapeutic avenues.
- Potential applications in stem cell therapies and treatments for conditions affecting stem cell populations.
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