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Updated: Aug 14, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
[Structure of surgumycin, a carbonyl-conjugated pentaenic antibiotic]
Abstract:
Degradation products of surgumycin, a pentaenic antibiotic, were investigated. Oxidation of perhydroantibiotic resulted in formation of brassilic acid. Ozonolysis of the antibiotic was followed by either complete reduction of the ozonolysis products and identification of the resultant hydrocarbon or oxidation by the glycol system and identification of the resultant polyols. The structure of the products of the antibiotic successive reduction was also studied. On the basis of the studies, the structure of 28-hydro-23-dehydroxy-24,29-dihydroxyflavofungin was assigned to surgumycin.
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