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Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

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Interobserver agreement of the old and the newly proposed ILAE epilepsy classification in children

Jolien S van Campen1, Floor E Jansen, Oebele F Brouwer

  • 1Department of Pediatric Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

Epilepsia
|February 5, 2013
PubMed

Insights

The 2010 International League Against Epilepsy (ILAE) classification for epilepsy and seizures did not significantly improve interobserver agreement. This study highlights areas needing further specification for better epilepsy diagnosis.

Area of Science:

  • Neurology
  • Epileptology
  • Clinical Classification

Background:

  • Accurate classification of epileptic seizures, epilepsies, and epilepsy syndromes is crucial for clinical practice and research.
  • The International League Against Epilepsy (ILAE) introduced a new classification scheme in 2010.

Purpose of the Study:

  • To evaluate if the new ILAE classification (2010) improves interobserver agreement compared to previous schemes (1981/1989).
  • To identify specific items within the classification that lead to interobserver disagreement.

Main Methods:

  • Retrospective classification of 165 seizures and epilepsies from 80 children by three pediatric neurologists.
  • Comparison of interobserver agreement using kappa statistics for both old and new ILAE classification schemes.

Main Results:

  • Interobserver agreement for the 2010 ILAE classification was comparable to previous classifications.
  • Substantial agreement was observed for the newly introduced etiologic axis.

Conclusions:

  • The introduction of the new epilepsy classification has not substantially improved interobserver agreement.
  • Specific items within the classification require further clarification to reduce interobserver disagreement.
Abstract

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