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Related Experiment Video

Updated: May 14, 2026

A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery
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A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery

Published on: October 19, 2021

Long-term ongoing cortical remodeling after contralateral C-7 nerve transfer.

Xu-Yun Hua1, Bin Liu, Yan-Qun Qiu

  • 1Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China.

Journal of Neurosurgery
|February 5, 2013
PubMed
Summary

Contralateral C-7 nerve transfer for brachial plexus avulsion injury (BPAI) shows long-term brain plasticity. Cortical reorganization continues for at least five years, enabling independent motor recovery.

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Area of Science:

  • Neuroscience
  • Neurosurgery
  • Rehabilitation Medicine

Background:

  • Brachial plexus avulsion injury (BPAI) treatment involves contralateral C-7 nerve transfer.
  • This procedure connects the affected nerve to the ipsilateral motor cortex, potentially inducing significant cortical reorganization.
  • Long-term outcomes of this cortical plasticity remain largely unexplored.

Purpose of the Study:

  • To investigate the long-term adaptive brain plasticity following BPAI and contralateral C-7 nerve transfer.

Main Methods:

  • Functional MRI studies were conducted on 9 healthy male volunteers and 5 male patients.
  • Patients had undergone contralateral C-7 nerve transfer more than 5 years prior for right-sided BPAI.
  • This approach assessed long-term cerebral plasticity.

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Structured Motor Rehabilitation After Selective Nerve Transfers
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Structured Motor Rehabilitation After Selective Nerve Transfers

Published on: August 15, 2019

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Last Updated: May 14, 2026

A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery
05:56

A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery

Published on: October 19, 2021

Structured Motor Rehabilitation After Selective Nerve Transfers
09:34

Structured Motor Rehabilitation After Selective Nerve Transfers

Published on: August 15, 2019

Main Results:

  • Neuroimaging indicated that cortical remodeling after contralateral C-7 nerve transfer persists for extended periods (at least 5 years).
  • Motor control for the reinnervated limb may shift exclusively to the contralateral hemisphere, rather than relying on bilateral activation.
  • This suggests a complete transfer of neural control.

Conclusions:

  • Cortical remodeling can occur over extended durations following peripheral nerve rearrangement.
  • Successful cortical transfer is crucial for achieving independent motor recovery after BPAI and nerve transfer surgery.