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Racial differences in mycosis fungoides: a retrospective study with a focus on eosinophilia
John G Zampella1, Ginette A Hinds
1Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Background:
Mycosis fungoides (MF) is often associated with eosinophilia and portends a poorer prognosis. MF is more common in blacks and follows a more aggressive course compared with whites.
Objective:
We further elucidate racial differences between blacks and whites with MF, focusing on blood eosinophilia.
Methods:
The records of 345 patients with MF were reviewed for demographic, clinical, and pathologic data and evaluated by analysis of variance.
Results:
The average age at diagnosis for blacks was 45 years and was 55 years for white patients (P < .001). In the cohorts of patients with and without blood eosinophilia, the average maximum blood eosinophil count had a greater range in blacks. Independent of race, blood eosinophilia was predictive of more advanced disease (P < .0001), increased number of treatment types (P < .002), and less responsiveness to treatment (P < .0006).
Limitations:
This was a retrospective study at a single institution.
Conclusions:
These differences observed in eosinophil values may highlight disparities in MF diagnosis or a difference in pathophysiology between races.
