Related Experiment Video
Updated: May 14, 2026
07:12
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
Epidemiology of primary hyperparathyroidism
1College of Medicine, Mayo Clinic, Rochester, MN, USA. Clarke.Bart@Mayo.edu
Summary
Primary hyperparathyroidism, a common endocrine disorder, requires more population-based studies. Further research is needed to fully understand its epidemiology, including mortality, hospitalizations, and costs.
Area of Science:
- Endocrinology
- Epidemiology
- Public Health
Background:
- Primary hyperparathyroidism is the third most common endocrine disorder.
- While its epidemiology is becoming clearer, significant knowledge gaps remain.
- Existing data is limited by a scarcity of population-based studies.
Purpose of the Study:
- To highlight the limitations in current understanding of primary hyperparathyroidism epidemiology.
- To emphasize the need for further research into key epidemiologic aspects.
Main Methods:
- Review of existing epidemiologic studies on primary hyperparathyroidism.
- Identification of knowledge gaps concerning mortality, hospitalizations, incidence, prevalence, and costs.
Main Results:
- Current understanding of primary hyperparathyroidism epidemiology is limited.
- Significant gaps exist in data regarding mortality, hospitalizations, incidence, prevalence, and associated costs.
- A lack of comprehensive, population-based studies hinders a full epidemiologic characterization.
Conclusions:
- Further population-based epidemiologic studies are essential.
- Comprehensive research is required to fully characterize the epidemiology of primary hyperparathyroidism.
- Addressing these research needs will improve understanding and management of this endocrine disorder.
Related Concept Videos
01:27Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
01:25Hyperthyroidism I: Introduction
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
00:59The Parathyroid Glands
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
01:24Graves Disease II: Pathophysiology
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
01:23Hypothyroidism II: Pathophysiology
Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
01:28Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...