Prostate-specific antigen-negative prostate cancer recurrence?
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Updated: May 14, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
Michael Froehner1, Nasreddin Abolmaali, Manfred P Wirth
1Department of Urology, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany. Michael.Froehner@uniklinikum-dresden.de
Abstract:
We describe a patient with bone metastases occurring shortly after radical prostatectomy for organ-confined prostate cancer. The medical history and immunohistochemical findings suggested prostate cancer recurrence to the skeleton. Undetectable serum prostate-specific antigen levels, however, raised doubts about this diagnosis. A whole body (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scan was obtained and revealed a right-sided breast cancer as the primary site of metastatic spread.

