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Updated: May 14, 2026
06:31
Identification and Dissection of Diverse Mouse Adipose Depots
Published on: July 11, 2019
The adipose tissue as an endocrine organ
Marcin Adamczak1, Andrzej Wiecek
1Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland.
Seminars in Nephrology
|February 5, 2013
Summary
White adipose tissue releases adipokines, impacting health. This review explores how key adipokines like leptin and adiponectin influence kidney disease, malnutrition, and cardiovascular issues.
Area of Science:
- Endocrinology
- Nephrology
- Cardiovascular Medicine
Background:
- White adipose tissue is an endocrine organ producing adipokines.
- Obesity-related adipokine dysregulation contributes to various pathologies.
- Adipokines play roles in endothelial dysfunction, inflammation, atherosclerosis, diabetes, and chronic kidney disease.
Purpose of the Study:
- To review the endocrine actions of specific adipokines.
- To discuss the role of adipokines in kidney diseases.
- To present the involvement of adipokines in malnutrition and cardiovascular complications in kidney disease patients.
Main Methods:
- Literature review of basic science and clinical studies.
- Focus on endocrine actions of leptin and adiponectin.
- Analysis of adipokine roles in chronic kidney disease progression and associated complications.
Main Results:
- Adipokines are crucial mediators in obesity-related diseases.
- Leptin and adiponectin significantly impact kidney disease pathogenesis.
- Adipokine imbalance is linked to malnutrition and cardiovascular risks in chronic kidney disease.
Conclusions:
- Adipokines are key players in the pathophysiology of kidney diseases.
- Understanding adipokine function is vital for managing chronic kidney disease and its complications.
- Targeting adipokines may offer therapeutic strategies for kidney and cardiovascular health.
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