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Related Experiment Video

Updated: May 14, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Structural renal changes in obesity and diabetes.

Kerstin Amann¹, Kerstin Benz

¹Department of Nephropathology, Department of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany. kerstin.amann@uk-erlangen.de

Seminars in Nephrology

|February 5, 2013

Summary

Obesity is a growing epidemic linked to chronic kidney disease, even without diabetes or hypertension. Weight loss interventions can improve kidney function and offer prevention strategies.

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Area of Science:

Nephrology
Endocrinology
Epidemiology

Background:

Overweight and obesity are escalating global health issues, now considered epidemic diseases.
Obesity's rising incidence in children and adolescents poses long-term risks, potentially reducing life expectancy.
Kidney diseases are increasingly recognized as significant comorbidities associated with obesity.

Purpose of the Study:

To review the pathogenesis and morphology of renal functional and structural changes in obesity.
To explore the link between obesity and associated renal diseases, including diabetic nephropathy.
To highlight the clinical relevance of weight loss in managing obesity-related kidney conditions.

Main Methods:

This review synthesizes evidence from epidemiologic studies and clinical observations.
It examines the mechanisms linking obesity to kidney dysfunction.
Pathological and functional changes in the kidneys due to obesity are discussed.

Main Results:

Obesity is an independent risk factor for chronic kidney disease, irrespective of diabetes or hypertension.
Mechanisms include adipokine abnormalities, renin-angiotensin system activation, inflammation, and impaired renal hemodynamics.
Obesity exacerbates primary renal diseases and impairs post-transplant function, leading to microalbuminuria, proteinuria, and hyperfiltration.

Conclusions:

Obesity significantly contributes to the development and progression of kidney disease.
Weight loss through lifestyle changes or bariatric surgery can improve renal parameters like albuminuria and hyperfiltration.
Renal disease in obesity is amenable to prevention and management strategies focused on weight reduction.