Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intracranial Pressure and Brain Tissue Oxygen Trajectories after Cardiac Arrest.

Neurocritical care·2026
Same author

Optimizing Radiography Utilization: Multidisciplinary Expert Consensus Recommendations Endorsed by the Society of Academic Bone Radiologists, Society of Skeletal Radiology, American Society of Emergency Radiology, Orthopaedic Trauma Association, American Academy of Emergency Medicine, and American Rhinologic Society.

Radiology·2026
Same author

Wolf Creek XVIII Part 6: transforming clinical trial design in cardiac arrest research.

Resuscitation plus·2026
Same author

Gender- and Sex-equitable Submission Guidelines in Emergency Medicine Journals Are Associated with Enhanced Publication Metrics.

The western journal of emergency medicine·2026
Same author

Temporal muscle thickness is associated with clinical frailty in patients with severe acute brain injury.

JAR life·2026
Same author

Design and rationale of the SPARC trial: a phase II, single-system randomized controlled trial of immediate transfer to specialty post-arrest care.

Resuscitation plus·2026
Same journal

Mechanical Versus Manual Cardiopulmonary Resuscitation Causing Traumatic Cardiothoracic and Abdominal Injuries: A Meta-Analysis and Systematic Review of Randomized Trials.

The Journal of emergency medicine·2026
Same journal

Drip-and-Ship versus Mothership Model in Acute Ischemic Stroke: A Meta-Analysis Stratified by Stroke System Integration.

The Journal of emergency medicine·2026
Same journal

Response to: "Letter to the Editor Regarding Cervical Spine Clearance in Adult and Pediatric Trauma: A Systematic Review".

The Journal of emergency medicine·2026
Same journal

Ultrasound Characterization of the Distal Thigh Great Saphenous Vein Dimensions in Children and Adults: Implications for Peripheral Rescue Access.

The Journal of emergency medicine·2026
Same journal

A Shadow in the Right Ventricle.

The Journal of emergency medicine·2026
Same journal

Structural Determinants of Telehealth Use Among Patients Presenting to an Urban Safety-Net Emergency Department.

The Journal of emergency medicine·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

Massive transfusion in traumatic shock.

Jonathan Elmer1, Susan R Wilcox, Ali S Raja

  • 1Department of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

The Journal of Emergency Medicine
|February 5, 2013
PubMed
Summary
This summary is machine-generated.

Massive transfusion protocols improve outcomes for patients with hemorrhagic shock by optimizing blood product ratios and managing complications. These protocols aim to reduce mortality and morbidity associated with large-volume resuscitation.

More Related Videos

Massive Pontine Hemorrhage by Dual Injection of Autologous Blood
06:33

Massive Pontine Hemorrhage by Dual Injection of Autologous Blood

Published on: May 29, 2021

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs
07:51

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs

Published on: May 21, 2019

Related Experiment Videos

Last Updated: May 14, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

Massive Pontine Hemorrhage by Dual Injection of Autologous Blood
06:33

Massive Pontine Hemorrhage by Dual Injection of Autologous Blood

Published on: May 29, 2021

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs
07:51

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs

Published on: May 21, 2019

Area of Science:

  • Trauma resuscitation
  • Hemorrhagic shock management
  • Blood product transfusion

Background:

  • Hemorrhage following trauma is a leading cause of death globally.
  • Key management goals include restoring oxygen delivery, maintaining circulatory volume, and controlling bleeding.
  • Massive transfusion may be required but carries dose-related adverse effects.

Observation:

  • Development and implementation of massive transfusion protocols (MTPs) are associated with reduced morbidity and mortality.
  • MTPs guide the optimal ratio of blood products for resuscitation.
  • Monitoring and correction of hypothermia, acidosis, and electrolyte abnormalities are crucial.

Findings:

  • Optimal MTPs commonly utilize a 1:1:1 ratio of packed red blood cells, fresh frozen plasma, and platelets.
  • Protocols should address coagulopathy, hypothermia, acidosis, and electrolyte disturbances.
  • Prevention of secondary coagulopathy is a key consideration.

Implications:

  • Massive transfusion protocols can significantly improve patient survival in hemorrhagic shock.
  • Standardized protocols enhance the management of complex transfusion-related complications.
  • Further research into optimal resuscitation strategies remains important.